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? 負(fù)責(zé)3個(gè)跨機(jī)構(gòu)科研合作項(xiàng)目的管理工作，合作方為香港中文大學(xué)。共管理資金500萬港幣，并通過起草和執(zhí)行資金管理策略，包括與銷售人員制定銷售協(xié)議，為兩機(jī)構(gòu)共節(jié)省20萬元港幣。管理過程中，按時(shí)以PPT和郵件方式向?qū)嶒?yàn)室負(fù)責(zé)人和合作伙伴匯報(bào)進(jìn)程，并和合作方管理人員保持緊密聯(lián)系以確保項(xiàng)目的順利進(jìn)行以及項(xiàng)目目標(biāo)的完成。 ? 管理3組由2到4名本科和博士生組成的研究團(tuán)隊(duì)，負(fù)責(zé)溝通解決項(xiàng)目進(jìn)行中出現(xiàn)的人事糾紛和技術(shù)性問題，并對(duì)科研問題給予專業(yè)指導(dǎo)。修改4篇由作者擬好的英文學(xué)術(shù)文章并輔助文章在國際期刊的順利發(fā)表。 ? 管理科研數(shù)據(jù)。 Managed 3 cross-organizational projects with total government grants worth of HK$5 million ? Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction ? Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations ? Monitored progress and ensured projects meet deadlines in a timely and accurate fashion ? Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved ? Negotiated with venders and achieved business agreements ? Provided regular updates on progress to lab director and collaborators through data presentations and written reports ? Provided expertise on study design and research methodology ? Troubleshooted experimental and technical problems ? Managed and securely stored data ? Reviewed 4 articles intended for publication in internally recognized journals ? 建立兩個(gè)可以用于商業(yè)化的 CRISPR-Cas9 基因敲除穩(wěn)定細(xì)胞系。 ? 建立了3個(gè)新型激酶在人體內(nèi)的作用對(duì)象的數(shù)據(jù)庫，并完善了利用概率來篩選和分析蛋白分子互動(dòng)對(duì)象的數(shù)學(xué)方法。 ? 設(shè)計(jì)并完成關(guān)于幾類新型激酶在卵巢癌和肝癌的發(fā)展和轉(zhuǎn)移中所起作用的研究，其中，明確確定了SBK1激酶在卵巢癌發(fā)展中的作用。研究中運(yùn)用到生物細(xì)胞學(xué)、生物化學(xué)、蛋白學(xué)、統(tǒng)計(jì)學(xué)和動(dòng)物模型等實(shí)驗(yàn)方法。 ? 與學(xué)院內(nèi)蛋白小分子、干細(xì)胞等實(shí)驗(yàn)組以及香港中文大學(xué)某實(shí)驗(yàn)室取得了合作，并帶領(lǐng)、輔導(dǎo)2支國外本科交流實(shí)習(xí)生隊(duì)伍參與與此課題相關(guān)的實(shí)驗(yàn)。 ? 起草并提交實(shí)驗(yàn)室科研經(jīng)費(fèi)申請(qǐng)。 Led a large-scale research project to investigate the activities of previously unknown kinases in ovarian and hepatic cancer ? Generated 2 CRISPR-Cas9 stable gene knockout cell lines available for commercial use ? Developed a probability-based algorithm to screen and analyze protein inter candidates ? Established kinase targets databases for 3 novel kinases ? Verified the mechanism of novel gene SBK1 in ovarian cancer metastasis ? Mentored 2 groups of international undergraduate interns ? Collaborated with teams in FHS and the Chinese University of Hong Kong ? Prepared and submitted proposals for grant applications in line with group strategies ? Executed a series of experiments on protein characterization, protein-protein inter and functional assays in vitro and in vivo

? 建立了與包括加拿大國家中子中心、 勞厄-朗之萬研究所（法國）、Helmholtz-Zentrum Berlin（HZB德國）、巴斯大學(xué)、拉塞福-阿普頓實(shí)驗(yàn)室、格拉斯哥大學(xué)和羅斯林研究所（英國）在內(nèi)的7所國際知名科研中心的學(xué)術(shù)合作，并多次獲得中子機(jī)構(gòu)給予的科研經(jīng)費(fèi)。期間與10多個(gè)由多學(xué)科人員組成的當(dāng)?shù)貓F(tuán)隊(duì)一起工作，與主要人員建立了長期合作關(guān)系。 ? 通過物理學(xué)和數(shù)據(jù)分析來研究艾滋海默癥病理。物理學(xué)采用包括光學(xué)、分子運(yùn)動(dòng)學(xué)和中子衍射等一系列物理學(xué)原理來學(xué)習(xí)該病病原淀粉樣蛋白的物理結(jié)構(gòu)及結(jié)構(gòu)變化，以及該蛋白在不同結(jié)構(gòu)下對(duì)細(xì)胞磷脂層的作用；數(shù)學(xué)主要應(yīng)用傅立葉變化將由中子衍射發(fā)出的信號(hào)轉(zhuǎn)變?yōu)榱字肿幽Ｐ停M(jìn)而分析磷脂在淀粉樣蛋白作用下的變化。博士畢業(yè)論文：淀粉樣蛋白和磷脂細(xì)胞的相互作用關(guān)系。 ? 創(chuàng)立了體外控制淀粉樣蛋白聚集的方法。 ? 改進(jìn)并完善了利用Langmuir膜和布魯斯特角顯微鏡來觀測磷脂單分子層在水與空氣交接面的狀態(tài)的方法。 Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics Thesis title: The inter between Amyloid beta peptide and lipid membranes ? Established collaborations with 7 world-renowned institutes including Canadian Neutron Beam Centre, The Institute Laue-Langevin, Helmholtz-Zentrum Berlin, University of Bath, Rutherford on Laboratory, University of Glasgow and the Roslin Institute ? Worked in 10+ multidisciplinary teams in Europe and Canada to identify the structural characteristics of amyloid protein and the biophysics of protein-lipid inters received neutron beam time al and traveling grants from neutron scattering facilities ? Performed mathematical analysis based on Fourier transform to generate membrane profile from neutron diffr data sets and predict protein penetration position ? Created a novel methodology to protein folding rate in non-physiological environments ? Improved Langmuir trough and Brewster Angle Microscopy techniques to monitor lipid mono dynamics at air-water interface

應(yīng)用物理和數(shù)學(xué)方法學(xué)習(xí)阿茲海默癥病理/ Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics

獸醫(yī)病理學(xué)/ Veterinary Pathology 獸醫(yī)臨床/ Veterinary Surgery 生物/ Biology 有機(jī)化學(xué)/ Organic Chemistry

負(fù)責(zé)3個(gè)跨機(jī)構(gòu)科研合作項(xiàng)目的管理工作，合作方為香港中文大學(xué)，共管理資金500萬港幣/ Managed 3 cross-organizational research projects with total government grants worth of HK$5 million

? 通過起草和執(zhí)行資金管理策略，包括與銷售人員制定銷售協(xié)議，為兩機(jī)構(gòu)共節(jié)省20萬元港幣。管理過程中，按時(shí)以PPT和郵件方式向?qū)嶒?yàn)室負(fù)責(zé)人和合作伙伴匯報(bào)進(jìn)程，并和合作方管理人員保持緊密聯(lián)系以確保項(xiàng)目的順利進(jìn)行以及項(xiàng)目目標(biāo)的完成。 ? 管理3組由2到4名本科和博士生組成的研究團(tuán)隊(duì)，負(fù)責(zé)溝通解決項(xiàng)目進(jìn)行中出現(xiàn)的人事糾紛和技術(shù)性問題，并對(duì)科研問題給予專業(yè)指導(dǎo)。修改4篇由作者擬好的英文學(xué)術(shù)文章并輔助文章在國際期刊的順利發(fā)表。 ? 管理科研數(shù)據(jù)。 ? Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction ? Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations ? Monitored progress and ensured projects meet deadlines in a timely and accurate fashion ? Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved ? Negotiated with venders and achieved business agreements ? Provided regular updates on progress to lab director and collaborators through data presentations and written reports ? Provided expertise on study design and research methodology ? Troubleshooted experimental and technical problems ? Managed and securely stored data ? Reviewed 4 articles intended for publication in internally recognized journals